AustralieFrV1, Main, Exploration, bibRecord, 008311

Genome-wide association study identifies three loci associated with melanoma risk

Identifieur interne : 008311 ( Main/Exploration ); précédent : 008310; suivant : 008312

Genome-wide association study identifies three loci associated with melanoma risk

Auteurs : D. Timothy Bishop [Royaume-Uni] ; Florence Demenais [France] ; Mark M. Iles [Royaume-Uni] ; Mark Harland [Royaume-Uni] ; John C. Taylor [Royaume-Uni] ; Eve Corda [France] ; Juliette Randerson-Moor [Royaume-Uni] ; Joanne F. Aitken [Australie] ; Marie-Francoise Avril [France] ; Esther Azizi [Israël] ; Bert Bakker [Pays-Bas] ; Giovanna Bianchi-Scarra [Italie] ; Brigitte Bressac-De Paillerets [France] ; Donato Calista [Italie] ; Lisa A. Cannon-Albright [États-Unis] ; Thomas Chin-A-Woeng [Pays-Bas] ; Tadeusz Debniak [Pologne] ; Gilli Galore-Haskel [Israël] ; Paola Ghiorzo [Italie] ; Ivo Gut [France] ; Johan Hansson [Suède] ; Marko Hocevar [Slovénie] ; Veronica Höiom [Suède] ; John L. Hopper [Australie] ; Christian Ingvar [Suède] ; Peter A. Kanetsky [États-Unis] ; Richard F. Kefford [Australie] ; Maria Teresa Landi [États-Unis] ; Julie Lang [Royaume-Uni] ; Jan Lubitiski [Pologne] ; Rona Mackie [Royaume-Uni] ; Josep Malvehy [Espagne] ; Graham J. Mann [Australie] ; Nicholas G. Martin [Australie] ; Grant W. Montgomery [Australie] ; Frans A. Van Nieuwpoort ; Srdjan Novakovic [Slovénie] ; Hakan Olsson [Suède] ; Susana Puig [Espagne] ; Marjan Weiss [Pays-Bas] ; Wilbert Van Workum [Pays-Bas] ; Diana Zelenika [France] ; Kevin M. Brown ; Alisa M. Goldstein [États-Unis] ; Elizabeth M. Gillanders ; Anne Boland [France] ; Pilar Galan ; David E. Elder ; Nelleke A. Gruis ; Nicholas K. Hayward [Australie] ; G. Mark Lathrop [France] ; Jennifer H. Barrett [Royaume-Uni] ; Julia A. Newton Bishop [Royaume-Uni]

Source :

Nature genetics [ 1061-4036 ] ; 2009.

RBID : Pascal:09-0347706

Descripteurs français

Pascal (Inist)
- Association, Identification, Locus, Risque, Mélanome malin, Echelle du génome.
Wicri :
- topic : Association.

English descriptors

KwdEn :
- Association, Identification, Locus, Malignant melanoma, Risk.

Abstract

We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two cohorts (1,149 selected cases and 964 controls from GenoMEL, and a population-based case-control study in Leeds of 1,163 cases and 903 controls). The genome-wide screen identified five loci with genotyped or imputed SNPs reaching P < 5 x 10^-7 . Three of these loci were replicated: 16q24 encompassing MC1R (combined P = 2.54 x 10^-27 for rs258322), 11 q14-q21 encompassing TYR (P = 2.41 × 10^-14 for rs1393350) and 9p21 adjacent to MTAP and flanking CDKN2A (P = 4.03 x 10^-7 for rs7023329). MC1 R and TYR are associated with pigmentation, freckling and cutaneous sun sensitivity, well-recognized melanoma risk factors. Common variants within the 9p21 locus have not previously been associated with melanoma. Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741419

Affiliations:

Australie, Espagne, France, Israël, Italie, Pays-Bas, Pologne, Royaume-Uni, Slovénie, Suède, États-Unis
Catalogne, Hollande-Méridionale, Maryland, Pennsylvanie, Svealand, Utah, Victoria (État), Écosse, Île-de-France
Barcelone, Glasgow, Leyde, Melbourne, Paris, Stockholm, Évry (Essonne)
Université de Glasgow, Université de Melbourne

Le document en format XML

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<affiliation wicri:level="4"><inist:fA14 i1="23"><s1>Departments of Medical Genetics and of Public Health & Health Policy, 1 Lilybank Gardens, University of Glasgow</s1>
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<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Malvehy, Josep" sort="Malvehy, Josep" uniqKey="Malvehy J" first="Josep" last="Malvehy">Josep Malvehy</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Melanoma Unit, Dermatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain and CIBER de Enfermedades Raras</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>32 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1>
<s2>Westmead</s2>
<s3>AUS</s3>
<sZ>27 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Westmead</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Queensland Institute of Medical Research</s1>
<s2>Herston, QLD</s2>
<s3>AUS</s3>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>50 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Queensland Institute of Medical Research</s1>
<s2>Herston, QLD</s2>
<s3>AUS</s3>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>50 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Nieuwpoort, Frans A" sort="Van Nieuwpoort, Frans A" uniqKey="Van Nieuwpoort F" first="Frans A." last="Van Nieuwpoort">Frans A. Van Nieuwpoort</name>
</author>
<author><name sortKey="Novakovic, Srdjan" sort="Novakovic, Srdjan" uniqKey="Novakovic S" first="Srdjan" last="Novakovic">Srdjan Novakovic</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institute of Oncology Ljubljana, Zaloska 2</s1>
<s2>Ljubljana</s2>
<s3>SVN</s3>
<sZ>22 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Slovénie</country>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olsson, Hakan" sort="Olsson, Hakan" uniqKey="Olsson H" first="Hakan" last="Olsson">Hakan Olsson</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Oncology, University Hospital Lund, Barngatan 2B</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>25 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Melanoma Unit, Dermatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain and CIBER de Enfermedades Raras</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>32 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weiss, Marjan" sort="Weiss, Marjan" uniqKey="Weiss M" first="Marjan" last="Weiss">Marjan Weiss</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Clinical Genetics, Center of Human and Clinical Genetics, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Workum, Wilbert" sort="Van Workum, Wilbert" uniqKey="Van Workum W" first="Wilbert" last="Van Workum">Wilbert Van Workum</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>ServiceXS, Plesmanlaan 1d</s1>
<s2>2333 BZ Leiden</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2333 BZ Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Commissariat à l'énergie Atomique, Institut de Génomique, Centre National de Génotypage</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>46 aut.</sZ>
<sZ>51 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name>
</author>
<author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name>
<affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>28 aut.</sZ>
<sZ>44 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name>
</author>
<author><name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Commissariat à l'énergie Atomique, Institut de Génomique, Centre National de Génotypage</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
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<sZ>46 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
</author>
<author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name>
</author>
<author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name>
</author>
<author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Queensland Institute of Medical Research</s1>
<s2>Herston, QLD</s2>
<s3>AUS</s3>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>50 aut.</sZ>
</inist:fA14>
<country>Australie</country>
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</affiliation>
</author>
<author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Fondation Jean Dausset-CEPH</s1>
<s2>75010, Paris</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Commissariat à l'énergie Atomique, Institut de Génomique, Centre National de Génotypage</s1>
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<sZ>20 aut.</sZ>
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<sZ>46 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
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</affiliation>
</author>
</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genome-wide association study identifies three loci associated with melanoma risk</title>
<author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERT, U946, Fondation Jean-Dausset-CEPH</s1>
<s2>75010 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>75010 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Harland, Mark" sort="Harland, Mark" uniqKey="Harland M" first="Mark" last="Harland">Mark Harland</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Taylor, John C" sort="Taylor, John C" uniqKey="Taylor J" first="John C." last="Taylor">John C. Taylor</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Corda, Eve" sort="Corda, Eve" uniqKey="Corda E" first="Eve" last="Corda">Eve Corda</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERT, U946, Fondation Jean-Dausset-CEPH</s1>
<s2>75010 Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>75010 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Fondation Jean Dausset-CEPH</s1>
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<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>51 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Randerson Moor, Juliette" sort="Randerson Moor, Juliette" uniqKey="Randerson Moor J" first="Juliette" last="Randerson-Moor">Juliette Randerson-Moor</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
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<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Viertel Centre for Research in Cancer Control, The Cancer Council, Queensland, Spring Hill</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Avril, Marie Francoise" sort="Avril, Marie Francoise" uniqKey="Avril M" first="Marie-Francoise" last="Avril">Marie-Francoise Avril</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>AP-HP, Hôpital Cochin, Service de Dermatologie, Faculté Paris 5</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Dermatology, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University</s1>
<s3>ISR</s3>
<sZ>10 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Israël</country>
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</affiliation>
</author>
<author><name sortKey="Bakker, Bert" sort="Bakker, Bert" uniqKey="Bakker B" first="Bert" last="Bakker">Bert Bakker</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Clinical Genetics, Center of Human and Clinical Genetics, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bianchi Scarra, Giovanna" sort="Bianchi Scarra, Giovanna" uniqKey="Bianchi Scarra G" first="Giovanna" last="Bianchi-Scarra">Giovanna Bianchi-Scarra</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Oncology, Biology and Genetics, University of Genoa</s1>
<s2>Genova</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genova</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Service de Génétique et FRE 2939 CNRS, Institut de Cancérologie Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut de Cancérologie Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Calista, Donato" sort="Calista, Donato" uniqKey="Calista D" first="Donato" last="Calista">Donato Calista</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Dermatology Unit, Maurizio Bufalini Hospital</s1>
<s2>Cesena</s2>
<s3>ITA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Cesena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cannon Albright, Lisa A" sort="Cannon Albright, Lisa A" uniqKey="Cannon Albright L" first="Lisa A." last="Cannon-Albright">Lisa A. Cannon-Albright</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Genetic Epidemiology, Biomedical Informatics, University of Utah</s1>
<s2>Salt Lake City, Utah</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chin A Woeng, Thomas" sort="Chin A Woeng, Thomas" uniqKey="Chin A Woeng T" first="Thomas" last="Chin-A-Woeng">Thomas Chin-A-Woeng</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>ServiceXS, Plesmanlaan 1d</s1>
<s2>2333 BZ Leiden</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2333 BZ Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>International Hereditary Cancer Center, Pomeranian Medical University</s1>
<s2>Szczecin</s2>
<s3>POL</s3>
<sZ>17 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Pologne</country>
<wicri:noRegion>Szczecin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Galore Haskel, Gilli" sort="Galore Haskel, Gilli" uniqKey="Galore Haskel G" first="Gilli" last="Galore-Haskel">Gilli Galore-Haskel</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Dermatology, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University</s1>
<s3>ISR</s3>
<sZ>10 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>Department of Dermatology, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Oncology, Biology and Genetics, University of Genoa</s1>
<s2>Genova</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Genova</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gut, Ivo" sort="Gut, Ivo" uniqKey="Gut I" first="Ivo" last="Gut">Ivo Gut</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Commissariat à l'énergie Atomique, Institut de Génomique, Centre National de Génotypage</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>46 aut.</sZ>
<sZ>51 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Oncology-Pathology, Karolinska Institutet</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institute of Oncology Ljubljana, Zaloska 2</s1>
<s2>Ljubljana</s2>
<s3>SVN</s3>
<sZ>22 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Slovénie</country>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hoiom, Veronica" sort="Hoiom, Veronica" uniqKey="Hoiom V" first="Veronica" last="Höiom">Veronica Höiom</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Oncology-Pathology, Karolinska Institutet</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="4"><inist:fA14 i1="17"><s1>Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, School of Population Health, University of Melbourne</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Ingvar, Christian" sort="Ingvar, Christian" uniqKey="Ingvar C" first="Christian" last="Ingvar">Christian Ingvar</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Oncology, University Hospital Lund, Barngatan 2B</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>25 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name>
<affiliation wicri:level="2"><inist:fA14 i1="19"><s1>Centre for Clinical Epidemiology & Biostatistics and Department of Biostatistics & Epidemiology, University of Pennsylvania</s1>
<s2>Philadephia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kefford, Richard F" sort="Kefford, Richard F" uniqKey="Kefford R" first="Richard F." last="Kefford">Richard F. Kefford</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1>
<s2>Westmead</s2>
<s3>AUS</s3>
<sZ>27 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Westmead</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name>
<affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>28 aut.</sZ>
<sZ>44 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lang, Julie" sort="Lang, Julie" uniqKey="Lang J" first="Julie" last="Lang">Julie Lang</name>
<affiliation wicri:level="4"><inist:fA14 i1="22"><s1>Department of Medical Genetics, University of Glasgow</s1>
<s3>GBR</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Lubitiski, Jan" sort="Lubitiski, Jan" uniqKey="Lubitiski J" first="Jan" last="Lubitiski">Jan Lubitiski</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>International Hereditary Cancer Center, Pomeranian Medical University</s1>
<s2>Szczecin</s2>
<s3>POL</s3>
<sZ>17 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Pologne</country>
<wicri:noRegion>Szczecin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mackie, Rona" sort="Mackie, Rona" uniqKey="Mackie R" first="Rona" last="Mackie">Rona Mackie</name>
<affiliation wicri:level="4"><inist:fA14 i1="23"><s1>Departments of Medical Genetics and of Public Health & Health Policy, 1 Lilybank Gardens, University of Glasgow</s1>
<s3>GBR</s3>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Malvehy, Josep" sort="Malvehy, Josep" uniqKey="Malvehy J" first="Josep" last="Malvehy">Josep Malvehy</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Melanoma Unit, Dermatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain and CIBER de Enfermedades Raras</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>32 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia</s1>
<s2>Westmead</s2>
<s3>AUS</s3>
<sZ>27 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Westmead</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Queensland Institute of Medical Research</s1>
<s2>Herston, QLD</s2>
<s3>AUS</s3>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>50 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Queensland Institute of Medical Research</s1>
<s2>Herston, QLD</s2>
<s3>AUS</s3>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>50 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Nieuwpoort, Frans A" sort="Van Nieuwpoort, Frans A" uniqKey="Van Nieuwpoort F" first="Frans A." last="Van Nieuwpoort">Frans A. Van Nieuwpoort</name>
</author>
<author><name sortKey="Novakovic, Srdjan" sort="Novakovic, Srdjan" uniqKey="Novakovic S" first="Srdjan" last="Novakovic">Srdjan Novakovic</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institute of Oncology Ljubljana, Zaloska 2</s1>
<s2>Ljubljana</s2>
<s3>SVN</s3>
<sZ>22 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Slovénie</country>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olsson, Hakan" sort="Olsson, Hakan" uniqKey="Olsson H" first="Hakan" last="Olsson">Hakan Olsson</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Oncology, University Hospital Lund, Barngatan 2B</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>25 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Melanoma Unit, Dermatology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain and CIBER de Enfermedades Raras</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>32 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weiss, Marjan" sort="Weiss, Marjan" uniqKey="Weiss M" first="Marjan" last="Weiss">Marjan Weiss</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Clinical Genetics, Center of Human and Clinical Genetics, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Workum, Wilbert" sort="Van Workum, Wilbert" uniqKey="Van Workum W" first="Wilbert" last="Van Workum">Wilbert Van Workum</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>ServiceXS, Plesmanlaan 1d</s1>
<s2>2333 BZ Leiden</s2>
<s3>NLD</s3>
<sZ>16 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>2333 BZ Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Commissariat à l'énergie Atomique, Institut de Génomique, Centre National de Génotypage</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>46 aut.</sZ>
<sZ>51 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name>
</author>
<author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name>
<affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>28 aut.</sZ>
<sZ>44 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name>
</author>
<author><name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Commissariat à l'énergie Atomique, Institut de Génomique, Centre National de Génotypage</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>46 aut.</sZ>
<sZ>51 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
</author>
<author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name>
</author>
<author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name>
</author>
<author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Queensland Institute of Medical Research</s1>
<s2>Herston, QLD</s2>
<s3>AUS</s3>
<sZ>34 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>50 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Fondation Jean Dausset-CEPH</s1>
<s2>75010, Paris</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>51 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Commissariat à l'énergie Atomique, Institut de Génomique, Centre National de Génotypage</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>46 aut.</sZ>
<sZ>51 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>52 aut.</sZ>
<sZ>53 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Identification</term>
<term>Locus</term>
<term>Malignant melanoma</term>
<term>Risk</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Association</term>
<term>Identification</term>
<term>Locus</term>
<term>Risque</term>
<term>Mélanome malin</term>
<term>Echelle du génome</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two cohorts (1,149 selected cases and 964 controls from GenoMEL, and a population-based case-control study in Leeds of 1,163 cases and 903 controls). The genome-wide screen identified five loci with genotyped or imputed SNPs reaching P < 5 x 10<sup>-7</sup>
 . Three of these loci were replicated: 16q24 encompassing MC1R (combined P = 2.54 x 10<sup>-27</sup>
 for rs258322), 11 q14-q21 encompassing TYR (P = 2.41 × 10<sup>-14</sup>
 for rs1393350) and 9p21 adjacent to MTAP and flanking CDKN2A (P = 4.03 x 10<sup>-7</sup>
 for rs7023329). MC1 R and TYR are associated with pigmentation, freckling and cutaneous sun sensitivity, well-recognized melanoma risk factors. Common variants within the 9p21 locus have not previously been associated with melanoma. Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Israël</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>Slovénie</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Catalogne</li>
<li>Hollande-Méridionale</li>
<li>Maryland</li>
<li>Pennsylvanie</li>
<li>Svealand</li>
<li>Utah</li>
<li>Victoria (État)</li>
<li>Écosse</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Glasgow</li>
<li>Leyde</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Stockholm</li>
<li>Évry (Essonne)</li>
</settlement>
<orgName><li>Université de Glasgow</li>
<li>Université de Melbourne</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name>
<name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name>
<name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
<name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name>
<name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name>
<name sortKey="Van Nieuwpoort, Frans A" sort="Van Nieuwpoort, Frans A" uniqKey="Van Nieuwpoort F" first="Frans A." last="Van Nieuwpoort">Frans A. Van Nieuwpoort</name>
</noCountry>
<country name="Royaume-Uni"><noRegion><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name>
</noRegion>
<name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name>
<name sortKey="Harland, Mark" sort="Harland, Mark" uniqKey="Harland M" first="Mark" last="Harland">Mark Harland</name>
<name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name>
<name sortKey="Lang, Julie" sort="Lang, Julie" uniqKey="Lang J" first="Julie" last="Lang">Julie Lang</name>
<name sortKey="Mackie, Rona" sort="Mackie, Rona" uniqKey="Mackie R" first="Rona" last="Mackie">Rona Mackie</name>
<name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name>
<name sortKey="Randerson Moor, Juliette" sort="Randerson Moor, Juliette" uniqKey="Randerson Moor J" first="Juliette" last="Randerson-Moor">Juliette Randerson-Moor</name>
<name sortKey="Taylor, John C" sort="Taylor, John C" uniqKey="Taylor J" first="John C." last="Taylor">John C. Taylor</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
</region>
<name sortKey="Avril, Marie Francoise" sort="Avril, Marie Francoise" uniqKey="Avril M" first="Marie-Francoise" last="Avril">Marie-Francoise Avril</name>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name>
<name sortKey="Corda, Eve" sort="Corda, Eve" uniqKey="Corda E" first="Eve" last="Corda">Eve Corda</name>
<name sortKey="Corda, Eve" sort="Corda, Eve" uniqKey="Corda E" first="Eve" last="Corda">Eve Corda</name>
<name sortKey="Gut, Ivo" sort="Gut, Ivo" uniqKey="Gut I" first="Ivo" last="Gut">Ivo Gut</name>
<name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name>
<name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name>
<name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name>
</country>
<country name="Australie"><noRegion><name sortKey="Aitken, Joanne F" sort="Aitken, Joanne F" uniqKey="Aitken J" first="Joanne F." last="Aitken">Joanne F. Aitken</name>
</noRegion>
<name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<name sortKey="Kefford, Richard F" sort="Kefford, Richard F" uniqKey="Kefford R" first="Richard F." last="Kefford">Richard F. Kefford</name>
<name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name>
<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
</country>
<country name="Israël"><noRegion><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name>
</noRegion>
<name sortKey="Galore Haskel, Gilli" sort="Galore Haskel, Gilli" uniqKey="Galore Haskel G" first="Gilli" last="Galore-Haskel">Gilli Galore-Haskel</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Bakker, Bert" sort="Bakker, Bert" uniqKey="Bakker B" first="Bert" last="Bakker">Bert Bakker</name>
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<name sortKey="Chin A Woeng, Thomas" sort="Chin A Woeng, Thomas" uniqKey="Chin A Woeng T" first="Thomas" last="Chin-A-Woeng">Thomas Chin-A-Woeng</name>
<name sortKey="Van Workum, Wilbert" sort="Van Workum, Wilbert" uniqKey="Van Workum W" first="Wilbert" last="Van Workum">Wilbert Van Workum</name>
<name sortKey="Weiss, Marjan" sort="Weiss, Marjan" uniqKey="Weiss M" first="Marjan" last="Weiss">Marjan Weiss</name>
</country>
<country name="Italie"><noRegion><name sortKey="Bianchi Scarra, Giovanna" sort="Bianchi Scarra, Giovanna" uniqKey="Bianchi Scarra G" first="Giovanna" last="Bianchi-Scarra">Giovanna Bianchi-Scarra</name>
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<name sortKey="Calista, Donato" sort="Calista, Donato" uniqKey="Calista D" first="Donato" last="Calista">Donato Calista</name>
<name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name>
</country>
<country name="États-Unis"><region name="Utah"><name sortKey="Cannon Albright, Lisa A" sort="Cannon Albright, Lisa A" uniqKey="Cannon Albright L" first="Lisa A." last="Cannon-Albright">Lisa A. Cannon-Albright</name>
</region>
<name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name>
<name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name>
<name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name>
</noRegion>
<name sortKey="Lubitiski, Jan" sort="Lubitiski, Jan" uniqKey="Lubitiski J" first="Jan" last="Lubitiski">Jan Lubitiski</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name>
</region>
<name sortKey="Hoiom, Veronica" sort="Hoiom, Veronica" uniqKey="Hoiom V" first="Veronica" last="Höiom">Veronica Höiom</name>
<name sortKey="Ingvar, Christian" sort="Ingvar, Christian" uniqKey="Ingvar C" first="Christian" last="Ingvar">Christian Ingvar</name>
<name sortKey="Olsson, Hakan" sort="Olsson, Hakan" uniqKey="Olsson H" first="Hakan" last="Olsson">Hakan Olsson</name>
</country>
<country name="Slovénie"><noRegion><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name>
</noRegion>
<name sortKey="Novakovic, Srdjan" sort="Novakovic, Srdjan" uniqKey="Novakovic S" first="Srdjan" last="Novakovic">Srdjan Novakovic</name>
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<country name="Espagne"><region name="Catalogne"><name sortKey="Malvehy, Josep" sort="Malvehy, Josep" uniqKey="Malvehy J" first="Josep" last="Malvehy">Josep Malvehy</name>
</region>
<name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name>
</country>
</tree>
</affiliations>
</record>

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Genome-wide association study identifies three loci associated with melanoma risk

Genome-wide association study identifies three loci associated with melanoma risk

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